Opening book details…
Can I read The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function on EtoBox?
The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function by Kay D. Gerold; Peilin Zheng; Daniel B. Rainbow; Alma Zernecke; Linda S. Wicker; Stephan Kissler is a Medicine article available to read on EtoBox.
What is The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function about?
## OBJECTIVE __CTLA4__ gene variation associates with multiple autoimmune disorders, including type 1 diabetes. The __CTLA4__ susceptibility allele was found to generate decreased levels of mRNA encoding soluble CTLA-4 (sCTLA-4) relative to the full-length isoform, the functional consequence of which is as yet unknown. In this study, we investigated the contribution of sCTLA-4 to immune regulation with the aim to elucidate the functional basis of the disease association of __CTLA4__. ## RESEARCH DESIGN AND METHODS To model the disease-associated splicing variation of __CTLA4__, we generated NOD mice in which sCTLA-4 mRNA is silenced by RNA interference. ## RESULTS We found that loss of sCTLA-4 impairs the function of regulatory T (Treg) cells. This functional defect could be attributed, at least in part, to the failure of sCTLA-4 knockdown (KD) Treg cells to downregulate dendritic cell costimulation. sCTLA-4 KD Treg cells, in contrast with wild-type Treg cells, failed to inhibit colitis induced by transfer of CD4^+^CD45RB^hi^ cells into NOD.SCID animals. Furthermore, diminished sCTLA-4 expression accelerated the onset of autoimmune diabetes in transgenic mice. ## CONCLUSIONS Our re
Who reads The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kay D. Gerold; Peilin Zheng; Daniel B. Rainbow; Alma Zernecke; Linda S. Wicker; Stephan Kissler
- Publisher
- American Diabetes Association (ISSN 0012-1797)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)