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Can I read Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication on EtoBox?
Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication by Carla Monteiro Leal; Suzana Guimarães Leitão; Romain Sausset; Simony C. Mendonça; Pedro H. A. Nascimento; Caio Felipe de Araujo R. Cheohen; Maria Eduarda A. Esteves; Manuela Leal da Silva; Tayssa Santos Gondim; Maria Eduarda S. Monteiro; Amanda Resende Tucci; Natália Fintelman-Rodrigues; Marilda M. Siqueira; Milene Dias Miranda; Fernanda N. Costa; Rosineide C. Simas; Gilda Guimarães Leitão is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication about?
The novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome, leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity. Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of 3,3′,4′-tri-O-methyl-quercetin, 3,7,3′,4′-tetra-O-methyl-quercetin (retusin), and 3,7-di-O-methyl-kaempferol (kumatakenin) from the dichloromethane extract of leaves of Siparuna cristata (Poepp. & Endl.) A.DC., Siparunaceae, using high-speed countercurrent chromatography in addition to the investigation of their inhibitory effect against SARS-CoV-2 viral replication. Retusin and kumatakenin inhibited SARS-CoV-2 replication in Vero E6 and Calu-3 cells, with a selective index greater than lopinavir/ritonavir and chloroquine, used as control. Flavonoids and their derivatives may stand for target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
Who reads Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Carla Monteiro Leal; Suzana Guimarães Leitão; Romain Sausset; Simony C. Mendonça; Pedro H. A. Nascimento; Caio Felipe de Araujo R. Cheohen; Maria Eduarda A. Esteves; Manuela Leal da Silva; Tayssa Santos Gondim; Maria Eduarda S. Monteiro; Amanda Resende Tucci; Natália Fintelman-Rodrigues; Marilda M. Siqueira; Milene Dias Miranda; Fernanda N. Costa; Rosineide C. Simas; Gilda Guimarães Leitão
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)