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Stridor and Death in Multiple System Atrophy by Michael H. Silber; Samantha Levine is a Medicine article available to read on EtoBox.

What is Stridor and Death in Multiple System Atrophy about?

Patients with multiple system atrophy (MSA) have a mean survival of 8 to 10 years. Nocturnal stridor has been considered a poor prognostic feature. We analyzed demographic, clinical, and polysomnographic data and obtained follow-up information from 42 patients with MSA (30 with follow-up data) seen in a Sleep Disorders Center. Group I consisted of 17 patients with nocturnal stridor, including seven with daytime stridor. Group II consisted of 25 patients without stridor. Analysis of survival curves of 30 patients with followup information showed a significantly shorter survival from the sleep evaluation, but not from disease onset, for patients with stridor compared with those without. Nine of 11 patients with stridor died a median of 2 years from presentation and the only two survivors had undergone tracheostomy. Patients with daytime stridor and immobile vocal cords had especially poor prognoses. However, two of four patients with tracheostomies also died, as did six of 19 without stridor. We postulate that central hypoventilation and its complications may have been responsible for many of these other deaths. We conclude that stridor does carry a poor prognosis in patients with MS

Who reads Stridor and Death in Multiple System Atrophy?

Author

Michael H. Silber; Samantha Levine

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2000

Language

EN

Field

Medicine (Health Sciences)