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Facile synthesis of a 4-anilinoquinazoline dimer by Suzuki cross-coupling reaction by Shao Peng Chen; Yue Sun; Sheng Biao Wan; Tao Jiang is a Chemistry article available to read on EtoBox.

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A novel 4-anilinoquinazoline dimer linked by a carbon-carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by 1 H NMR, 13 C NMR, and HRMS. The inhibition rate of the synthetic 4-anilinoquinazoline dimer 8 against epidermal growth factor receptor-tyrosine kinase enzymes (EGFR) in vitro was 44.4% at the concentration of 5.5 mmol/L.

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Author

Shao Peng Chen; Yue Sun; Sheng Biao Wan; Tao Jiang

Publisher

Chinese Electronic Periodical Services; Elsevier ; Elsevier BV (ISSN 1001-8417)

Published

2011

Language

EN

Field

Chemistry (Physical Sciences)