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Comparison of 5% human albumin and normal saline for fluid resuscitation in sepsis induced hypotension among patients with cirrhosis (FRISC study): a randomized controlled trial by Cyriac Abby Philips; Rakhi Maiwall; Manoj Kumar Sharma; Ankur Jindal; Ashok Kumar Choudhury; Guresh Kumar; Ankit Bhardwaj; Lalita Gouri Mitra; Prashant Mohan Agarwal; Shiv Kumar Sarin is a Medicine article available to read on EtoBox.

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## Aims: Sepsis and septic shock are common causes of hospitalization and mortality in patients with cirrhosis. there is no data on the choice of fluid and resuscitation protocols in sepsis-induced hypotension in cirrhosis. ## Methods: In this open-label trial conducted at a single center, we enrolled 308 cirrhotics with sepsis-induced hypotension and randomized them to receive either 5% albumin or normal saline. the primary endpoint was a reversal of hypotension [mean arterial pressure, map, ≥ 65 mmhg] at 3 h. secondary endpoints included serial effects on heart rate, arterial lactate and urine output. ## Results: 154 patients each received 5% albumin (males, 79.8%, mean map 52.9 ± 7.0 mm hg) or 0.9% saline (85.1%, 53.4 ± 6.3 mm hg) with comparable baseline parameters and liver disease severity. reversal of hypotension was higher in patients receiving 5% albumin than saline at the end of one hour [25.3% and 11.7%, p = 0.03, odds ratio (95% ci)-1.9 (1.08-3.42)] and at the end of three hours [11.7% and 3.2%, p = 0.008, 3.9 (1.42-10.9)]. sustained reduction in heart rate and hyperlactatemia (p < 0.001) was better in the albumin group. at one week, the proportion of patients surviving

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Author

Cyriac Abby Philips; Rakhi Maiwall; Manoj Kumar Sharma; Ankur Jindal; Ashok Kumar Choudhury; Guresh Kumar; Ankit Bhardwaj; Lalita Gouri Mitra; Prashant Mohan Agarwal; Shiv Kumar Sarin

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)