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Identification of a eukaryotic-like protein kinase gene in Archaebacteria by Randall F. Smith; Katherine Y. King is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Primary sequence patterns based on known conserved sites in eukaryotic protein kinases were used to search for eukaryotic‐like protein kinase sequences in a six‐frame translation of the bacterial subsection of GenBank. This search identified a previously unrecognized eukaryotic‐like protein kinase gene in three related methanogenic archaebacteria, __Methanococcus vannielii, M. voltae__, and __M. thermolithotrophicus__. The proposed coding sequences are located in orthologous open reading frames (ORFs): ORF547, ORF294, and ORF114, respectively. The C‐terminus of the ORFs contains 9 of the 11 subdomains characteristically conserved within the eukaryotic protein kinase catalytic domain. The N‐terminus of the ORFs is similar to a putative glycoprotease in __Pasteurella haemolytica__ and its homologue in __Escherichia coli__, the __orfX__ gene. This is the first report of a eukaryotic‐like protein kinase sequence observed in Archaebacteria.

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Author

Randall F. Smith; Katherine Y. King

Publisher

Cold Spring Harbor Laboratory Press; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0961-8368)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)