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Can I read Counting on random number generation: Uncovering mild executive dysfunction in congenital heart disease on EtoBox?
Counting on random number generation: Uncovering mild executive dysfunction in congenital heart disease by Ladina Schlosser; Nadja Naef; Melanie Ehrler; Flavia Wehrle; Matthias Greutmann; Angela Oxenius; Ruth Tuura; Beatrice Latal; Peter Brugger is a Neuroscience article available to read on EtoBox.
What is Counting on random number generation: Uncovering mild executive dysfunction in congenital heart disease about?
Congenital heart disease (CHD) is associated with various neurocognitive deficits, particularly targeting executive functions (EFs), of which random number generation (RNG) is one indicator. RNG has, however, never been investigated in CHD. We administered the Mental Dice Task (MDT) to 67 young adults with CHD and 55 healthy controls. This 1-minute-task requires the generation of numbers 1 to 6 in a random sequence. RNG performance was correlated with a global EF score. Participants underwent MRI to examine structural-volumetric correlates of RNG. Compared to controls, CHD patients showed increased backward counting, reflecting deficient inhibition of automatized behavior. They also lacked a small-number bias (higher frequency of small relative to large numbers). RNG performance was associated with global EF scores in both groups. In CHD patients, MRI revealed an inverse association of counting bias with most of the volumetric measurements and the amount of small numbers was positively associated with corpus callosum volume, suggesting callosal involvement in the “pseudoneglect in number space”. In conclusion, we found an impaired RNG performance in CHD patients, which is associate
Who reads Counting on random number generation: Uncovering mild executive dysfunction in congenital heart disease?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Ladina Schlosser; Nadja Naef; Melanie Ehrler; Flavia Wehrle; Matthias Greutmann; Angela Oxenius; Ruth Tuura; Beatrice Latal; Peter Brugger
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)