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Can I read Novel Inhibitors of Fatty Acid Amide Hydrolase on EtoBox?
Novel Inhibitors of Fatty Acid Amide Hydrolase by S.Y. Sit; Charlie Conway; Robert Bertekap; Kai Xie; Clotilde Bourin; Kevin Burris; Hongfeng Deng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Novel Inhibitors of Fatty Acid Amide Hydrolase about?
A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH). Compound 17 (IC 50 = 2 nM) dose-dependently (0.1-10 mg/kg, iv) potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models of persistent (formalin test) and neuropathic (Chung model) pain. Compound 17 (20 mg/kg, iv) demonstrates activity in the formalin test that is comparable to morphine (3 mg/kg, iv), and is dose-dependently inhibited by the CB1 antagonist SR141716A. In the Chung model, compound 17 shows antineuropathic effects similar to high-dose (100 mg/kg) gabapentin. FAAH inhibition shows potential utility for the clinical treatment of persistent and neuropathic pain.
Who reads Novel Inhibitors of Fatty Acid Amide Hydrolase?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- S.Y. Sit; Charlie Conway; Robert Bertekap; Kai Xie; Clotilde Bourin; Kevin Burris; Hongfeng Deng
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- ZU
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)