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Diabetes Exacerbates Inflammatory Bowel Disease in Mice with Diet-induced Obesity by Kendra L Francis; Kimberly M Alonge; Maria Cristina Pacheco; Shannon J Hu; Cody A Krutzsch; Gregory J Morton; Michael W Schwartz; Jarrad M Scarlett is a Medicine article available to read on EtoBox.

What is Diabetes Exacerbates Inflammatory Bowel Disease in Mice with Diet-induced Obesity about?

## BACKGROUND The increased prevalence of inflammatory bowel disease (IBD) among patients with obesity and type 2 diabetes suggests a causal link between these diseases, potentially involving the effect of hyperglycemia to disrupt intestinal barrier integrity. ## AIM To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced obesity. ## METHODS Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range hyperglycemia. Six weeks later, dextran sodium sulfate was given to induce colitis. In select experiments, a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis onset. Endpoints included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier integrity. ## RESULTS In mice given a high-fat diet, but not chow-fed animals, diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease severity. Diabetes was also associated with a decrease in key comp

Who reads Diabetes Exacerbates Inflammatory Bowel Disease in Mice with Diet-induced Obesity?

Author

Kendra L Francis; Kimberly M Alonge; Maria Cristina Pacheco; Shannon J Hu; Cody A Krutzsch; Gregory J Morton; Michael W Schwartz; Jarrad M Scarlett

Publisher

Baishideng Publishing Group Inc.

Published

2023

Language

EN

Field

Medicine (Health Sciences)