About this document
Sulfonamides: Discovery and Mechanism by Ahmed Madbouly is a document available to read on EtoBox.
This document summarizes sulfonamides, including their discovery through the observation that Prontosil cured streptococcal infections in mice but not in cultures, their mechanism of action by competing with PABA in bacterial folic acid synthesis, and their structure-activity relationships. Sulfonamides are bacteriostatic by inhibiting dihydropteroate synthase. Resistance can develop through alternate folic acid synthesis, increased cell wall permeability to folic acid, or increased PABA production.
- Author
- Ahmed Madbouly
- Language
- EN