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Injectable Oxidized Alginate/carboxylmethyl Chitosan Hydrogels Functionalized with Nanoparticles for Wound Repair by Lei Ma; Yunfei Tan; Xiangyu Chen; Yaqin Ran; Qiulan Tong; Liwen Tang; Wen Su; Xiaoliang Wang; Xudong Li is a Materials Science article available to read on EtoBox.

What is Injectable Oxidized Alginate/carboxylmethyl Chitosan Hydrogels Functionalized with Nanoparticles for Wound Repair about?

Owing to its simple properties, the application of injectable hydrogel in wound repair is limited. Therefore, the multi-functionalization of injectable hydrogel to improve the therapeutic effect is imperative. Here, keratin nanoparticles (Ker NPs) with facilitating epithelization capability and nanosized-EGCG covered with Ag nanoparticles (AE NPs) with radicals scavenging capability were used to functionalize injectable oxidized alginate/carboxylmethyl chitosan hydrogel (KA hydrogel). The radical scavenging experiments proved the anti-oxidative capacity of AE NPs. Rheological test exhibited that the gelation time and storage modulus of KA hydrogel were about 216 s and 403 Pa. Additionally, wound healing experiment in vivo showed that KA hydrogel could accelerated wound healing, especially in the early stage, and improved the thickness of renascent epidermis by 21 %. In this work, Ker NPs and AE NPs functionalization endowed injectable hydrogels with the capabilities of scavenging radicals and facilitating epithelization, which is promising for the applications in wound repair.

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Author

Lei Ma; Yunfei Tan; Xiangyu Chen; Yaqin Ran; Qiulan Tong; Liwen Tang; Wen Su; Xiaoliang Wang; Xudong Li

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)