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Validation of Published Rebound Hyperbilirubinemia Risk Prediction Scores During Birth Hospitalization After Initial Phototherapy: a Retrospective Chart Review by Vincent So; Helen Coo; Faiza Khurshid is a Medicine article available to read on EtoBox.
What is Validation of Published Rebound Hyperbilirubinemia Risk Prediction Scores During Birth Hospitalization After Initial Phototherapy: a Retrospective Chart Review about?
## Background: Hyperbilirubinemia commonly affects newborns and may lead to neurotoxicity if untreated. neonates can experience rebound hyperbilirubinemia (rhb), defined as elevated bilirubin levels requiring re-initiation of treatment. although studies have formulated risk prediction scores, they lack external validation. in this study, we examine the discrimination and calibration performance of risk prediction scores for rhb, to provide external validation. ## Methods: We reviewed charts of neonates born ≥35 weeks of gestation between january 2015 and december 2019 receiving phototherapy at birth hospitalization. we plotted predicted probabilities against observed outcome proportions to assess model calibration and evaluated discrimination using area under the receiver operating characteristic (auroc) curves. odds ratios (ors) were estimated to evaluate variables associated with rhb. ## Results: Of the 271 infants identified, 24% developed rhb. two- and three-variable prediction scores had lower discrimination in our cohort with auroc of 0.662 (95% ci 0.590-0.735) and 0.691 (95% ci, 0.619-0.763) compared to 0.876 (95% ci 0.854-0.899) and 0.881 (95% ci 0.859-0.903), respectively,
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- Author
- Vincent So; Helen Coo; Faiza Khurshid
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)