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USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma by Wenjin Qiu; Zumu Xiao; Yushi Yang; Lishi Jiang; Shibin Song; Xiaolan Qi; Yimin Chen; Hua Yang; Jian Liu; Liangzhao Chu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma about?
The mesenchymal (MES) subtype of glioblastoma (GBM) is a highly aggressive, malignant and proliferative cancer that is resistant to chemotherapy. Runt-related transcription factor 1 (RUNX1) was shown to support MES GBM, however, its underlying mechanisms are unclear. Here, we identified USP10 as a deubiquitinating enzyme that regulates RUNX1 stabilization and is mainly expressed in MES GBM. Overexpression of USP10 upregulated RUNX1 and induced proneural-to-mesenchymal transition (PMT), thus maintaining MES properties in GBM. Conversely, USP10 knockdown inhibited RUNX1 and resulted in the loss of MES properties. USP10 was shown to interact with RUNX1, with RUNX1 being stabilized upon deubiquitylation. Moreover, we found that USP10 inhibitor Spautin-1 induced RUNX1 degradation and inhibited MES properties in vitro __and__ in vivo. Furthermore, USP10 was strongly correlated with RUNX1 expression in samples of different subtypes of human GBM and had prognostic value for GBM patients. We identified USP10 as a key deubiquitinase for RUNX1 protein stabilization. USP10 maintains MES properties of GBM, and promotes PMT of GBM cells. Our study indicates that the USP10/RUNX1 axis may be a pot
Who reads USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wenjin Qiu; Zumu Xiao; Yushi Yang; Lishi Jiang; Shibin Song; Xiaolan Qi; Yimin Chen; Hua Yang; Jian Liu; Liangzhao Chu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)