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## Summary **objective** Because in recent years the practice of TSH suppression has changed, and thyroxine doses have been reduced significantly in the treatment of patients with low‐risk differentiated thyroid cancer, the goal of this study was to determine the time needed to attain a target TSH level (of 30 mIU/l) following levothyroxine withdrawal in patients treated with thyroxine according to current guidelines, in anticipation of radioactive iodine (RAI) administration. **design** Observational study. **patients** Thirteen consecutive patients with differentiated thyroid cancer on suppressive doses of levothyroxine planned for RAI administration. Five of the patients received cholestyramine in an attempt to facilitate TSH recovery. **measurements** Serum TSH, free‐T3 and free‐T4, at 3–4‐day intervals. **results** In 13 patients on suppressive doses of thyroxine, on 15 separate occasions, baseline TSH levels were between 0·01 and 0·4 mIU/l. The mean interval required to reach the target TSH concentration of at least 30 mIU/l was 17 days (95% CI 15–19; range 11–28 days). Cholestyramine had no effect on the rate of TSH recovery. Once TSH concentration became detectable, it incr

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Author

Yair Liel

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2002

Language

EN

Field

Medicine (Health Sciences)