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Serum growth hormone (GH) binding protein, IGF-I and IGFBP-3 in patients with beta-thalassaemia major and the effect of GH treatment by L. C. K. Low; M. C. Postel‐Vinay; E. Y. W. Kwan; P. T. Cheung is a Medicine article available to read on EtoBox.

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## Objective: Levels of igfi have been shown to be low in transfusion-dependent thalassaemia and there is preliminary evidence to suggest that this may be reversed by gh treatment. in this further study we have evaluated serum growth hormone (gh) binding protein (ghbp), igf-i and igfbp-3 in patients with beta-thalassaemia major and the effects of gh treatment on these various parameters. ## Patients: Fifty-six transfusion dependent patients with beta-thalassaemia major without gh deficiency between 2 and 20 years of age were studied. thirteen non-gh deficient patients with heights of -1.5 sd or more were treated with gh at a dose of 0.14 iu/kg/day subcutaneously for 1 year. ## Measurements: Serum ghbp, igf-i and igfbp-3 were measured in all the patients. in the 13 patients treated with gh, these serum parameters were measured before and after 3, 6 and 12 months of treatment. ## Results: The mean serum ghbp concentrations were normal in both prepubertal and pubertal children but the serum igf-i and igfbp-3 concentrations were low throughout childhood and adolescence. there was a significant correlation between serum igf-i and igfbp-3 concentrations (r = 0.79; p = 0.0001) but there w

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Author

L. C. K. Low; M. C. Postel‐Vinay; E. Y. W. Kwan; P. T. Cheung

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1998

Language

EN

Field

Medicine (Health Sciences)