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Hyperhomocysteinemia, DNA methylation and vascular disease by Md S. Jamaluddin; Xiaofeng Yang; Hong Wang is a Medicine article available to read on EtoBox.

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## Abstract Hyperhomocysteinemia (HHcy) has been established as a potent independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is largely unknown. We were the first to propose that hypomethylation is the key biochemical mechanism by which homocysteine (Hcy) inhibits endothelial cell (EC) growth. We reported that clinically relevant concentrations of Hcy (10–50 μmol/L) exerts highly selective inhibitory effects on cyclin A transcription and EC growth through a hypomethylation related mechanism, which blocks cell cycle progression and endothelium regeneration. Recently, we demonstrated that Hcy reduces DNA methyltransferase 1 (DNMT1) activity and demethylates cyclin A promoter leading to cyclin A chromatin remodeling. We found that adenovirus-transduced Clin Chem Lab Med 2007;45:1660–6.

Who reads Hyperhomocysteinemia, DNA methylation and vascular disease?

Author

Md S. Jamaluddin; Xiaofeng Yang; Hong Wang

Publisher

Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 1434-6621)

Published

2007

Language

EN

Field

Medicine (Health Sciences)