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The Role of Gut Microbiota in Hypertension Pathogenesis and the Efficacy of Antihypertensive Drugs by Yanling Xiong; Yalan Xiong; Peng Zhu; Yusheng Wang; Haijun Yang; Rong Zhou; Yan Shu; Honghao Zhou; Qing Li is a Medicine article available to read on EtoBox.

What is The Role of Gut Microbiota in Hypertension Pathogenesis and the Efficacy of Antihypertensive Drugs about?

## Purpose of heading: To review the relationship between intestinal microbes and hypertension and its impact on the efficacy of antihypertensive drugs, and help to address some of these knowledge gaps. ## Recent findings: Hypertension is associated with cardiovascular diseases and is the most important modifiable risk factor for all-cause morbidity and mortality worldwide. the pathogenesis of hypertension is complex, including factors such as dietary, environmental and genetics. recently, the studies have shown that the gut microbiota influences the occurrence and development of hypertension through a variety of ways, including affecting the production of short-chain fatty acids, dysfunction of the brain-gut axis, and changes in serotonin content that cause the imbalance of vagus and sympathetic nerve output associated with hypertension. however, patients with hypertension typically take antihypertensive drugs orally on a long-term basis, and most antihypertensive drugs are absorbed by the gastrointestinal tract. studies have shown that the pharmacokinetics and metabolism of antihypertensive drugs may be influenced by microbiota, or antihypertensive drugs act directly on the intes

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Author

Yanling Xiong; Yalan Xiong; Peng Zhu; Yusheng Wang; Haijun Yang; Rong Zhou; Yan Shu; Honghao Zhou; Qing Li

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)