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Survival and Biomarkers for Cachexia in Non‐small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors by Daiki Murata; Koichi Azuma; Norikazu Matsuo; Kenta Murotani; Goushi Matama; Akihiko Kawahara; Tetsuro Sasada; Takaaki Tokito; Tomoaki Hoshino is a Medicine article available to read on EtoBox.
What is Survival and Biomarkers for Cachexia in Non‐small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors about?
## Abstract ## Background The presence of cachexia negatively impacts the prognosis of patients with cancer. However, the mechanisms behind the development of cachexia and its prognostic impact on immunotherapy efficacy are not fully understood. ## Materials and Methods We retrospectively screened patients with advanced or recurrent non‐small cell lung cancer (NSCLC) who received PD‐1/PD‐L1 inhibitor monotherapy. Among 183 patients, pre‐treatment plasma samples were available from 100 patients. We defined cancer cachexia as weight loss of at least 5% during the past 6 months or weight loss of at least 2% and BMI <20. We analyzed 75 soluble immune mediators in pre‐treatment plasma samples to explore the possible mechanisms behind the development of cancer cachexia. We also investigated whether cancer cachexia affects prognosis. ## Results Among 100 patients, 35 had cancer cachexia. Logistic regression analysis identified ghrelin, c‐reactive protein (CRP), pentraxin‐3 (PTX‐3), and osteopontin (OPN) as factors associated with cachexia. Patients with cachexia had worse progression‐free survival (PFS) and overall survival (OS), although we did not detect statistically significant differ
Who reads Survival and Biomarkers for Cachexia in Non‐small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Daiki Murata; Koichi Azuma; Norikazu Matsuo; Kenta Murotani; Goushi Matama; Akihiko Kawahara; Tetsuro Sasada; Takaaki Tokito; Tomoaki Hoshino
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)