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Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries by de Jesus, Vivianne Cruz (author);Khan, Mohd Wasif (author);Mittermuller, Betty-Anne (author);Duan, Kangmin (author);Hu, Pingzhao (author);Schroth, Robert J. (author);Chelikani, Prashen (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries about?
The human oral cavity harbors one of the most diverse microbial communities with different oral microenvironments allowing the colonization of unique microbial species. This study aimed to determine which of two commonly used sampling sites (dental plaque vs. oral swab) would provide a better prediction model for caries-free vs. severe early childhood caries (S-ECC) using next generation sequencing and machine learning (ML). In this cross-sectional study, a total of 80 children (40 S-ECC and 40 caries-free) < 72 months of age were recruited. Supragingival plaque and oral swab samples were used for the amplicon sequencing of the V4-16S rRNA and ITS1 rRNA genes. The results showed significant differences in alpha and beta diversity between dental plaque and oral swab bacterial and fungal microbiomes. Differential abundance analyses showed that, among others, the cariogenic species __Streptococcus mutans__ was enriched in the dental plaque, compared to oral swabs, of children with S-ECC. The fungal species __Candida dubliniensis__ and __C. tropicalis__ were more abundant in the oral swab samples of children with S-ECC compared to caries-free controls. They were also among the top 20 m
Who reads Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- de Jesus, Vivianne Cruz (author);Khan, Mohd Wasif (author);Mittermuller, Betty-Anne (author);Duan, Kangmin (author);Hu, Pingzhao (author);Schroth, Robert J. (author);Chelikani, Prashen (author)
- Publisher
- Frontiers Media SA
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)