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Can I read USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization on EtoBox?
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization by Chenming Wu; Kuntian Luo; Fei Zhao; Ping Yin; Ying Song; Min Deng; Jinzhou Huang; Yuping Chen; Lei Li; SeungBaek Lee; JungJin Kim; Qin Zhou; Xinyi Tu; Somaira Nowsheen; Qifeng Luo; Xiumei Gao; Zhenkun Lou; Zhongmin Liu; Jian Yuan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization about?
β-catenin is a major transcriptional activator of the canonical Wnt/β-catenin signaling pathway. It is important for a series of biological processes including tissue homeostasis, and embryonic development and is involved in various human diseases. Elevated oncogenic activity of β-catenin is frequently observed in cancers, which contributes to survival, metastasis and chemo-resistance of cancer cells. However, the mechanism of β-catenin overexpression in cancers is not well defined. Here we demonstrate that the deubiquitination enzyme USP20 is a new regulator of the Wnt/β-catenin signaling pathway. Mechanistically, USP20 regulates the deubiquitination of β-catenin to control its stability, thereby inducing proliferation, invasion and migration of cancer cells. High expression of USP20 correlates with increased β-catenin protein level in multiple cancer cell lines and patient samples. Moreover, knockdown of USP20 increases β-catenin polyubiquitination, which enhances β-catenin turnover and cell sensitivity to chemotherapy. Collectively, our results establish the USP20-β-catenin axis as a critical regulatory mechanism of canonical Wnt/β-catenin signaling pathway with an important rol
Who reads USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Chenming Wu; Kuntian Luo; Fei Zhao; Ping Yin; Ying Song; Min Deng; Jinzhou Huang; Yuping Chen; Lei Li; SeungBaek Lee; JungJin Kim; Qin Zhou; Xinyi Tu; Somaira Nowsheen; Qifeng Luo; Xiumei Gao; Zhenkun Lou; Zhongmin Liu; Jian Yuan
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1350-9047)
- Published
- 2018
- Language
- EN
- ISBN
- 9784141801801
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)