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Milanick et al. demonstrate that presynaptic α2δs are crucial for regulating Munc13-1 levels, a key protein for neurotransmitter release, but are not necessary for synapse development or ultrastructure in the mammalian brain. Their findings indicate that while α2δs influence synaptic gain and plasticity, they do not affect the organization of presynaptic CaV2.1 channels or the overall morphology of synapses. This research provides new insights into the regulatory roles of α2δs in synaptic function without i

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jaypig2012

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