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Accelerated Early Vascular Aging Among Adolescents With Obesity and/or Type 2 Diabetes Mellitus by Justin R. Ryder; Elise Northrop; Kyle D. Rudser; Aaron S. Kelly; Zhiqian Gao; Philip R. Khoury; Thomas R. Kimball; Lawrence M. Dolan; Elaine M. Urbina is a Medicine article available to read on EtoBox.

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## Background The normal rate of subclinical vascular aging from adolescence to young adulthood has not been well‐characterized. We conducted a 5‐year longitudinal study among adolescents with normal‐weight, obesity, and/or type 2 diabetes mellitus to examine trajectories of early vascular aging. ## Methods and Results Adolescents (mean [SD] age 17.6 [3.5]; 35.3% male) had either normal weight (n=141), obesity (n=156), or type 2 diabetes mellitus (n=151) at baseline. Primary metrics used for early vascular aging included measures of vascular structure (carotid intima‐media thickness [cIMT]; common, internal, and bulb) and arterial stiffness (carotid‐femoral pulse wave velocity, and augmentation index). Longitudinal (5‐year) outcomes were examined using generalized estimating equations adjusting for baseline value, sex, race, and age. Compared with participants with normal weight, those with obesity had greater positive change in common cIMT (0.05 mm [0.03, 0.06]; __P__<0.001), bulb cIMT (0.02 mm [0.00, 0.05]; __P__=0.033), internal cIMT (0.03 mm [0.01, 0.05]; __P__<0.001), and pulse wave velocity carotid‐femoral (0.38 m/sec [0.14, 0.61]; __P__=0.001), and those with type 2 diabetes

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Author

Justin R. Ryder; Elise Northrop; Kyle D. Rudser; Aaron S. Kelly; Zhiqian Gao; Philip R. Khoury; Thomas R. Kimball; Lawrence M. Dolan; Elaine M. Urbina

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)