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Liver Regeneration and the Effect of Exogenous Putrescine on Regenerative Activity After Partial Hepatectomy in Cirrhotic Rats by Ethel Macintosh; Tony Gauthier; Norman Pettigrew; Dr. Gerald Minuk is a Medicine article available to read on EtoBox.

What is Liver Regeneration and the Effect of Exogenous Putrescine on Regenerative Activity After Partial Hepatectomy in Cirrhotic Rats about?

There are conflicting data regarding the ability of the liver to regenerate after partial hepatectomy in animals and humans with cirrhosis. The purpose of this study was to document liver regeneration after partial hepatectomy in a carbon tetrachloride rat model of cirrhosis and to determine whether exogenous putrescine, a polyamine that has been reported to stimulate liver regeneration in animal models of acute liver failure, enhances regenerative activity in cirrhosis. Liver fibrosis and cirrhosis were produced by weekly intragastric gavage with carbon tetrachloride in 130 adult male rats. Vehicle-gavaged rats (n = 12) served as healthy controls. At surgery and at 4 and 8 hr after 70% hepatectomy, rats received normal saline solution or 1 or 10 mg/kg putrescine by intraperitoneal injection. Another group (n = 32) of carbon tetrachloride-treated rats was given putrescine (100 mg/kg) or normal saline solution twice daily for 10 days before partial hepatectomy and at 0, 4 and 8 hr after partial hepatectomy. Liver regeneration was documented 24 and 48 hr after partial hepatectomy on the basis of restitution of liver mass, ornithine decarboxylase activity and [3H]thymidine incorporati

Who reads Liver Regeneration and the Effect of Exogenous Putrescine on Regenerative Activity After Partial Hepatectomy in Cirrhotic Rats?

Author

Ethel Macintosh; Tony Gauthier; Norman Pettigrew; Dr. Gerald Minuk

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1992

Language

EN

Field

Medicine (Health Sciences)