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The document discusses the Sonogashira coupling reaction, a palladium-catalyzed process for forming carbon-carbon bonds between aryl or alkenyl halides and terminal alkynes, first discovered by Kenkichi Sonogashira in 1975. It outlines the reaction mechanism, applications in organic synthesis, and its significance in drug development, while also addressing challenges such as side reactions and the potential for copper-free variants. The Sonogashira reaction is highlighted for its versatility in creating com
- Author
- krishnakhetre6
- Language
- EN