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Multifunctional Hydrogel Loaded with 4-Octyl Itaconate Exerts Antibacterial, Antioxidant and Angiogenic Properties for Diabetic Wound Repair by Qiuyue Ding; Xirui Jing; Sheng Yao; Weijie Su; Bing Ye; Yanzhen Qu; Fei Gao; Tingfang Sun; Xiaodong Guo is a Engineering article available to read on EtoBox.
What is Multifunctional Hydrogel Loaded with 4-Octyl Itaconate Exerts Antibacterial, Antioxidant and Angiogenic Properties for Diabetic Wound Repair about?
Cutaneous wound healing, especially diabetic wound healing, is a common clinical problem. Reactive oxygen species (ROS) and bacterial infection are two major factors in the induction of oxidative stress and inflammation, leading to impeded angiogenesis and wound healing. However, it is still very difficult to reverse the harsh microenvironment of chronic inflammation and excessive oxidative stress on diabetic wound. Itaconate, an endogenous metabolite, has recently attracted extensive attention as a critical immune-regulator. In this study, we used 4-octyl itaconate (4OI), a cell-permeable itaconate derivative, to have antioxidative and antiinflammatory functions for diabetic wound regeneration. Simultaneously, an injectable, self-healing, and antibacterial dynamic coordinative hydrogel was manufactured by binding the 4-arm polyethylene glycol (PEG) with silver nitrate to deliver the bioactive molecule. In vitro experiments confirmed that 4OI@PEG hydrogel could inhibit bacterial growth, protect human umbilical vein endothelial cells from ROS damage and enhance neovascularization. In addition, the hydrogel increased mitochondrial polarization and reduced mitochondrial fragmentation
Who reads Multifunctional Hydrogel Loaded with 4-Octyl Itaconate Exerts Antibacterial, Antioxidant and Angiogenic Properties for Diabetic Wound Repair?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Qiuyue Ding; Xirui Jing; Sheng Yao; Weijie Su; Bing Ye; Yanzhen Qu; Fei Gao; Tingfang Sun; Xiaodong Guo
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)