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Cedden et al. present a study on optimizing double-stranded RNA (dsRNA) sequences for RNA interference (RNAi) in pest control, focusing on the red flour beetle, Tribolium castaneum. The research identifies key sequence features that enhance the efficacy of dsRNA, such as thermodynamic asymmetry and specific nucleotide compositions, and introduces the dsRIP web platform for designing effective dsRNA sequences. This work aims to improve RNAi-based pest management strategies while minimizing risks to non-targe

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y1342474280

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EN