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Determination of Drug Enantiomers in Biological Samples by Coupled Column Liquid Chromatography and Liquid Chromatography-mass Spectrometry by Lars-Erik Edholm; Claes Lindberg; Jan Paulson; Agneta Walhagen is a Chemistry article available to read on EtoBox.

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Liquid chromatography-mass spectrometry (LC-MS) and coupled column chmm&ogmphy can be used to overcome problems likely to occur in direct separation and determination of drug enantiomers in biological samples. This is exemplified here with the direct separation and determination of terbutaline in human plasma at the nmol/l level. A fi-cyclodextrin column with an aqueous mobile phase was used for chiral separation. For coupled column chromatography, the concentration of each enantiomer was calculated from the enantiomeric area ratio and the racemate concentration. A deuterium-labelled internal standard was used in the LC-MS experiments.

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Author

Lars-Erik Edholm; Claes Lindberg; Jan Paulson; Agneta Walhagen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1988

Language

EN

Field

Chemistry (Physical Sciences)