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The expression and function of the B7 family in Helicobacter pylori infection and gastric carcinogenesis process by Yuan Zhang; Zhenkun Zhao; Weiwei Fu; Shigang Ding is a Medicine article available to read on EtoBox.

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## Abstract ## Background The B7 protein family is one of the most important immune checkpoint proteins. Gastric cancer (GC) is the fourth most common cause of cancer‐related mortality worldwide and shows a significant correlation with the B7 family in tumorigenesis and progression. Helicobacter pylori infection is the most important risk factor promoting the progression of gastric precancerous lesions and GC, which also affects the expression of B7 family members. We aimed to systematically summarize and review current studies on the expression and function of B7 family members during H. pylori infection in precancerous gastric lesions and GC. ## Materials and Methods PubMed was searched for the relationship between B7 family, H. pylori and gastric carcinogenesis until April 5, 2023. Different permutation and combination of the search terms, including “H. pylori,” “Helicobacter pylori,” “B7,” “gastric cancer,” and “gastric precancerous lesions,” all the different names of specific B7 molecules, and the names of signaling pathways were used. Literature related to our research topic was selected and summarized. ## Results The B7 family participates in gastric carcinogenesis through

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Author

Yuan Zhang; Zhenkun Zhao; Weiwei Fu; Shigang Ding

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)