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Niaspan Increases Angiogenesis and Improves Functional Recovery After Stroke by Jieli Chen; Xu Cui; Alex Zacharek; Hao Jiang; Cynthia Roberts; Chunling Zhang; Mei Lu; Alissa Kapke; Carolyn S. Feldkamp; Michael Chopp is a Medicine article available to read on EtoBox.

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## Abstract ## Objective High‐density lipoprotein (HDL) is implicated in the modulation of angiogenesis. In this study, we investigated whether the Niacin‐mediated increase of HDL regulates angiogenesis and thereby improves functional outcome after stroke. ## Methods Adult male rats were subjected to middle cerebral artery occlusion and were treated with or without different doses (40 and 80mg/kg) of Niaspan, starting 24 hours after middle cerebral artery occlusion and daily for 14 days. Neurological functional tests were performed, and serum HDL level was measured. Angiogenesis and angiogenic factor expression were measured by immunohistochemistry, corneal neovascularization and capillary tube formation assay, and Western blot, respectively. ## Results Niaspan significantly increased HDL level, promoted angiogenesis in the ischemic brain, and improved functional outcome after stroke. Niaspan also significantly increased corneal neovascularization compared with nontreatment control. Mechanisms underlying the Niaspan‐induced vascular remodeling were investigated. Niaspan increased the expression of vascular endothelial growth factor and angiopoietin‐1 (Ang1), and phosphorylation of

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Author

Jieli Chen; Xu Cui; Alex Zacharek; Hao Jiang; Cynthia Roberts; Chunling Zhang; Mei Lu; Alissa Kapke; Carolyn S. Feldkamp; Michael Chopp

Publisher

Wiley

Published

2007

Language

EN

Field

Medicine (Health Sciences)