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Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy by Xu-Jun Qin; Wei He; Chun-Xu Hai; Xin Liang; Rui Liu is a Environmental Science article available to read on EtoBox.

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## Abstract Adriamycin is an effective anthracycline anti‐tumor antibiotic. However, the clinical use of adriamycin has been restricted by its serious side effects. Some reports indicated that the side effects of adriamycin could cause systemic injury, in which reactive oxygen species (ROS) play an important role. ROS are a large family of oxygen free radical and non‐free radical active oxygen‐containing molecules, including superoxide radical, hydrogen peroxide and hydroxyl radical, which contribute to oxidative stress. Although antioxidant treatment is a promising method to prevent the side effects, protection by a single antioxidant is limited. The Chinese herbal medicine ANTIOXIN is a multiple antioxidant that can effectively block oxidative stress. It was hypothesized that ANTIOXIN could effectively reduce the side effects of adriamycin. A rat tumor model with a transplanted tumor in the liver was treated with adriamycin and ANTIOXIN was used as a protection. Oxidative stress and antioxidant enzymes were evaluated. The results showed that adriamycin chemotherapy increased the level of malondialdehyde (MDA), nitrogen oxide (NO) and decreased the activities of total superoxide d

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Author

Xu-Jun Qin; Wei He; Chun-Xu Hai; Xin Liang; Rui Liu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2007

Language

EN

Field

Environmental Science (Physical Sciences)