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HOXA10 inhibit the osteogenic differentiation of periodontal ligament stem cells by regulating Î2-catenin localization and DKK1 expression by Wang, Chengze; Li, Yongzheng; Yu, Ke; Jiang, Zhiwei; Wang, Ying; Yang, Guoli is a Medicine article available to read on EtoBox.

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: Human periodontal ligament stem cells (hPDLSCs) are stem cells found near the tooth periodontal ligament. These cels are involved in the regeneration of the periodontal ligament and alveolar bone during orthodontic treatment and chronic periodontitis.: The Homeobox gene HOXA10 regulates the osteogenic differentiation of stem cells. However, the role of HOXA10 in hPDLSCs remains unclear. Therefore, we studied the effects of HOXA10 on human PDLSC osteogenic differentiation .: First, hPDLSCs were isolated and characterized. Second, we assessed the effects of overexpression and knockdown of HOXA10 on PDLSC osteogenic differentiation. Finally, the specific Wnt signaling pathway activator lithium chloride (LiCl) and inhibitor ICG-001 were used to investigate the involvement of the Wnt signaling pathway in HOXA10-induced regulation of osteogenic differentiation.: Overexpressing HOXA10 inhibited PDLSC osteogenic differentiation , shown by ALP and Alizarin Red staining, while HOXA10 knockdown demonstrated the opposite effects. HOXA10 negatively regulated nuclear β-catenin and osteogenic differentiation markers including alkaline phosphatase () and integrin-binding sialoprotein (). Upregul

Who reads HOXA10 inhibit the osteogenic differentiation of periodontal ligament stem cells by regulating Î2-catenin localization and DKK1 expression?

Author

Wang, Chengze; Li, Yongzheng; Yu, Ke; Jiang, Zhiwei; Wang, Ying; Yang, Guoli

Publisher

Informa plc; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 0300-8207)

Published

2020

Language

EN

Field

Medicine (Health Sciences)