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Engineered Polymeric Nanovector for Intracellular Peptide Delivery in Antitumor Therapy by Xi Zhang; Mingming Zhang; Sijun Huang; Kiyoshi Ohtani; Li Xu; Yi Guo is a Materials Science article available to read on EtoBox.

What is Engineered Polymeric Nanovector for Intracellular Peptide Delivery in Antitumor Therapy about?

## Objective This study aimed to deliver a polypeptide from the Bax-BH3 domain (BHP) through the synthesis of self-assembled amphiphile nanovectors (NVs) and to assess their potential for cancer therapeutic applications and biological safety in vitro and in vivo. These findings provide valuable options for cancer intervention and a novel approach for the rational design of therapeutics. ## Methods We studied the antitumor activity of BHP by preparing RGDfK-PHPMA-b-Poly (MMA-__alt__-(Rhob-MA)) (RPPMMRA) and encapsulating it in BHP-NV. We also performed a series of characterizations and property analyses of RPPMMRA, including its size, stability, and drug-carrying capacity. The biocompatibility of RPPMMRA was evaluated in terms of cytotoxicity and hemolytic effects. The pro-apoptotic capacity of BHP was evaluated in vitro using mitochondrial membrane potential, flow cytometry, and apoptosis visualization techniques. The potential therapeutic effects of BHP on tumors were explored using reverse molecular docking. We also investigated the in vivo proapoptotic effect of BHP-NV in a nude mouse tumor model. ## Results NVs were successfully prepared with hydrated particle sizes ranging fro

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Author

Xi Zhang; Mingming Zhang; Sijun Huang; Kiyoshi Ohtani; Li Xu; Yi Guo

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)