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Paramagnetic Relaxation Agents for Enhancing Temporal Resolution and Sensitivity in Multinuclear FlowNMR Spectroscopy by Alejandro Bara‐Estaún; Marie C. Harder; Catherine L. Lyall; John P. Lowe; Elizaveta Suturina; Ulrich Hintermair is a Chemistry article available to read on EtoBox.
What is Paramagnetic Relaxation Agents for Enhancing Temporal Resolution and Sensitivity in Multinuclear FlowNMR Spectroscopy about?
Sensitivity in FlowNMR spectroscopy for reaction monitoring often suffers from low levels of pre-magnetisation due to limited residence time of the sample in the magnetic field. While this in-flow effect is tolerable for high sensitivity nuclei such as 1 H and 19 F, it significantly reduces the signal-to-noise ratio in 31 P and C spectra, making FlowNMR impractical especially at low analyte concentrations. Paramagnetic relaxation agents (PRAs), which enhance polarisation and spin-lattice relaxation, could eliminate the adverse in-flow effect and improve the signal-to-noise ratio. Here, we investigate [Co(acac)3], [Mn(acac)3], [Fe(acac)3], [Cr(acac)3], [Ni(acac)2]3, [Gd(tmhd)3] and [Cr(tmhd)3] for their effectiveness in improving signal intensity per unit time in FlowNMR applications under the additional constraint of chemical inertness towards catalytically active transition metal complexes. Highspin Cr(III)acetylacetonates emerged as the most effective compounds successfully reducing 31 P T1 values four-to five-fold at concentrations as low as 10 mM without causing adverse line broadening. Whereas [Cr(acac)3] showed signs of chemical reactivity with a mixture of triphenylphosphine
Who reads Paramagnetic Relaxation Agents for Enhancing Temporal Resolution and Sensitivity in Multinuclear FlowNMR Spectroscopy?
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- Author
- Alejandro Bara‐Estaún; Marie C. Harder; Catherine L. Lyall; John P. Lowe; Elizaveta Suturina; Ulrich Hintermair
- Publisher
- John Wiley and Sons Inc.
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)