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Can I read miRNA interplay: mechanisms and consequences in cancer on EtoBox?
miRNA interplay: mechanisms and consequences in cancer by Meredith Hill; Nham Tran is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is miRNA interplay: mechanisms and consequences in cancer about?
## ABSTRACT Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology. We also discuss the cell-type-specific nature of miRNA:miRNA interactions, current experimental approaches and bioinformatic techniques, and how these strategies are not sufficient for the identification of novel miRNA:miRNA interactions. The self-regulation of miRNAs and their impact on gene regulation has yet to be fully understood. Investigating this hidden world of miRNA self-regulation will assist in discovering novel regulatory mechanisms associated with disease pathways.
Who reads miRNA interplay: mechanisms and consequences in cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Meredith Hill; Nham Tran
- Publisher
- The Company of Biologists
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)