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Can I read Arrhythmogenic late Ca^2+^ sparks in failing heart cells and their control by action potential configuration on EtoBox?
Arrhythmogenic late Ca^2+^ sparks in failing heart cells and their control by action potential configuration by Ewan D. Fowler; Nan Wang; Melanie Hezzell; Guillaume Chanoit; Jules C. Hancox; Mark B. Cannell is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Arrhythmogenic late Ca^2+^ sparks in failing heart cells and their control by action potential configuration about?
## Significance Sudden cardiac death in heart failure is a major unsolved clinical problem that is linked to the development of a spontaneous arrhythmia. Early afterdepolarizations (EADs) are an arrhythmogenic mechanism, but the cellular trigger for EADs in heart failure is unclear. We show that the reduction in synchronous Ca^2+^ release early in the action potential (AP) of failing cardiac myocytes promotes the appearance of late Ca^2+^ sparks which can propagate, forming Ca^2+^ ripples and waves. These, in turn, produce an inward sodium–calcium exchange current which opposes AP repolarization. Restoration of AP phase 1 repolarization improved Ca^2+^ release synchrony and reduced late Ca^2+^ spark rate, suggesting a different approach to reducing the risk of sudden death in heart failure.
Who reads Arrhythmogenic late Ca^2+^ sparks in failing heart cells and their control by action potential configuration?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ewan D. Fowler; Nan Wang; Melanie Hezzell; Guillaume Chanoit; Jules C. Hancox; Mark B. Cannell
- Publisher
- National Academy of Sciences; Proceedings of the National Academy of Sciences; Oxford University Press (OUP); Publons; ScienceOpen (ISSN 0027-8424)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)