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Effects of lipoproteins on cyclosporine a toxicity and uptake in LLC-PK1 pig kidney cells by Kathy D. Peteherych; Kishor M. Wasan is a Chemistry article available to read on EtoBox.
What is Effects of lipoproteins on cyclosporine a toxicity and uptake in LLC-PK1 pig kidney cells about?
Cyclosporine A (CSA) is an effective immunosuppressant, but side effects such as renal toxicity can limit its therapeutic use. The current studies investigate the effects of lipoproteins on CSA-induced renal toxicity in the pig epithelial cell line LLC-PK 1 . Protein synthesis and tritiated CSA were used as measures of toxicity and uptake of CSA, respectively, in the LLC-PK 1 cell line. The three main classes of lipoproteins, very low (VLDL), low (LDL), and high density lipoproteins (HDL) at hypo-, normo-, and hyperlipidemic levels were tested for their ability to affect CSA-induced toxicity and uptake. The major component of each lipoprotein was also tested to determine its effects on CSA-induced toxicity and uptake. ApoA-I, the major protein component of HDL, and intact LDL particles showed the most signi®cant effects of CSA uptake and toxicity. The uptake and toxicity of CSA was effectively reduced with elevated LDL concentrations but showed a signi®cant increase (p `0.05) when incubated with elevated concentrations of apoA-I. Increasing VLDL and HDL concentrations slightly reduced CSA toxicity and uptake, but showed little effect with increased incubation time. Triglyceride and
Who reads Effects of lipoproteins on cyclosporine a toxicity and uptake in LLC-PK1 pig kidney cells?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Kathy D. Peteherych; Kishor M. Wasan
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2001
- Language
- EN
- Field
- Chemistry (Physical Sciences)