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Myotonic dystrophy: Calcium-dependent phosphatidic acid synthesis in erythrocytes by Dr. R. B. Moore; S. H. Appel; G. A. Plishker is a Medicine article available to read on EtoBox.

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## Abstract Recently it was reported that calcium‐dependent phosphatidic acid synthesis in erythrocytes of patients with myotonic muscular dystrophy (MyD) is markedly impaired when compared to that in control subjects. Using ^32^P‐loaded erythrocytes, we found no significant difference in the levels of ^32^P‐phosphatidic acid synthesized after exposure to calcium and its ionophore A23187 between patients with MyD and controls. In a batch experiment typical of the experiments with ^32^P, a twofold increase of phosphatidic acid in both groups was determined by inorganic phosphate measurements. Thus, the specific activity of the ^32^P‐phosphatidic acid increased four‐ to five‐fold in response to calcium. Analyses of ^32^P‐polyphosphoinositide breakdown in ghosts and in adenosine triphosphate‐depleted erythrocytes also appeared normal for patients with myotonic muscular dystrophy. Possible discrepancies between the results presented here and those reported previously are discussed.

Who reads Myotonic dystrophy: Calcium-dependent phosphatidic acid synthesis in erythrocytes?

Author

Dr. R. B. Moore; S. H. Appel; G. A. Plishker

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)

Published

1981

Language

EN

Field

Medicine (Health Sciences)