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Can I read Irradiation Enhances the Support of Haemopoietic Cell Transmigration, Proliferation and Differentiation by Endothelial Cells on EtoBox?
Irradiation Enhances the Support of Haemopoietic Cell Transmigration, Proliferation and Differentiation by Endothelial Cells by Marie-Hélène Gaugler; Claire Squiban; Marc-André Mouthon; Patrick Gourmelon; Anne Van der Meeren is a Medicine article available to read on EtoBox.
What is Irradiation Enhances the Support of Haemopoietic Cell Transmigration, Proliferation and Differentiation by Endothelial Cells about?
Endothelial cells (ECs) are a critical component of the bone marrow stroma in the regulation of haemopoiesis. Recovery of bone marrow aplasia after radiation exposure depends, in part, on the repair of radiation-induced endothelial damage. Therefore, we assessed the ability of an irradiated human bone marrow EC line (TrHBMEC) to support transmigration, proliferation and differentiation of CD34+ bone marrow cells either irradiated or not in transendothelial migration or co-culture models. Radiation-induced EC damage was reflected by an increased release of soluble intercellular adhesion molecule (sICAM)-1 and platelet endothelial cell adhesion molecule (PECAM)-1. Irradiation of TrHBMECs with a 10 Gy dose strongly enhanced the transmigration of CD34+ cells, granulo-monocytic progenitors (CFU-GM) and erythroid progenitors (BFU-E). While ICAM-1 and PECAM-1 expression on irradiated TrHBMECs was increased, only antibodies against PECAM-1 inhibited the radiation-induced enhanced transmigration of haemopoietic cells. Irradiation of TrHBMECs (5-15 Gy) also increased proliferation and differentiation towards the granulo-monocytic lineage of co-cultured CD34+ cells, as well as colony formatio
Who reads Irradiation Enhances the Support of Haemopoietic Cell Transmigration, Proliferation and Differentiation by Endothelial Cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Marie-Hélène Gaugler; Claire Squiban; Marc-André Mouthon; Patrick Gourmelon; Anne Van der Meeren
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)