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Felodipine Improves Pulmonary Hemodynamics in Chronic Obstructive Pulmonary Disease by Dimitar Sajkov; R. Douglas McEvoy; Ritchie J. Cowie; Julie A. Bradley; Ral Antic; Raymond G. Morris; Beter A. Frith is a Medicine article available to read on EtoBox.

What is Felodipine Improves Pulmonary Hemodynamics in Chronic Obstructive Pulmonary Disease about?

Pulmonary hypertension in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis. Reduction of pulmonary artery pressure in COPD by prolonged oxygen treatment has been shown to be associated with increased survival. In an attempt to 6nd a suitable pharmacologic method of reducing pulmonary artery pressure and pulmonary vascular resistance in COPD, we enrolled 13 stable pulmonary-hypertensive, hypoxemic COPD patients in a study to test the effects of felodipine, a relatively new, vascular-selective calcium antagonist. Doppler echocardiography was used to estimate pulmonary artery pressure and cardiac output before treatment, 2, 7, and 12 weeks during felodipine treatment (10 to 20 mgld), and after a I-week placebo washout period. Measurements of lung function, arterial blood gases, and exercise capacity during an incremental bicycle ergometer test were also performed at intervals during the study period. Three patients withdrew from the study and of the remaining 10, 8 had some side effects of medication (peripheral edema or headache) that improved either spontaneously or following P ulmonary hypertension is a frequent complication of chronic obstructive pu

Who reads Felodipine Improves Pulmonary Hemodynamics in Chronic Obstructive Pulmonary Disease?

Author

Dimitar Sajkov; R. Douglas McEvoy; Ritchie J. Cowie; Julie A. Bradley; Ral Antic; Raymond G. Morris; Beter A. Frith

Publisher

Elsevier BV

Published

1993

Language

EN

Field

Medicine (Health Sciences)