Can I read Transplantation of Glutamatergic Neuronal Precursor Cells in the Paraventricular Thalamus and Claustrum Facilitates Awakening with Recovery of Consciousness on EtoBox?

Transplantation of Glutamatergic Neuronal Precursor Cells in the Paraventricular Thalamus and Claustrum Facilitates Awakening with Recovery of Consciousness by Tong Zhao; Naili Wei; Tianwen Li; Kezhu Chen; Wenqiang Cui; Zhifu Wang; Fan Wang; Yuanxiang Lin; Jianhong Zhu is a Neuroscience article available to read on EtoBox.

What is Transplantation of Glutamatergic Neuronal Precursor Cells in the Paraventricular Thalamus and Claustrum Facilitates Awakening with Recovery of Consciousness about?

## Abstract ## Background Stem cells offer a promising therapeutic strategy for patients with disorders of consciousness (DOC) after severe traumatic brain injury (TBI), but the optimal transplantation sites and cells are not clear. Although the paraventricular thalamus (PVT) and claustrum (CLA) are associated with consciousness and are candidate transplantation targets, few studies have been designed to investigate this possibility. ## Methods Controlled cortical injury (CCI) was performed to establish a mouse model of DOC. CCI‐DOC paradigm was established to investigate the role of excitatory neurons of PVT and CLA in disorders of consciousness. The role of excitatory neuron transplantation in promoting arousal and recovery of consciousness was determined by optogenetics, chemogenetics, electrophysiology, Western blot, RT‐PCR, double immunofluorescence labeling, and neurobehavioral experiments. ## Results After CCI‐DOC, neuronal apoptosis was found to be concentrated in the PVT and CLA. Prolonged awaking latency and cognitive decline were also seen after destruction of the PVT and CLA, suggesting that the PVT and CLA may be key nuclei in DOC. Awaking latency and cognitive perform

Who reads Transplantation of Glutamatergic Neuronal Precursor Cells in the Paraventricular Thalamus and Claustrum Facilitates Awakening with Recovery of Consciousness?

Author

Tong Zhao; Naili Wei; Tianwen Li; Kezhu Chen; Wenqiang Cui; Zhifu Wang; Fan Wang; Yuanxiang Lin; Jianhong Zhu

Publisher

Wiley

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)