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Progression of liver fibrosis in women infected with hepatitis C: Long-term benefit of estrogen exposure by Vincent Di Martino; Pascal Lebray; Robert P. Myers; Emmanuelle Pannier; Valérie Paradis; Frédéric Charlotte; Joseph Moussalli; Dominique Thabut; Catherine Buffet; Thierry Poynard is a Medicine article available to read on EtoBox.

What is Progression of liver fibrosis in women infected with hepatitis C: Long-term benefit of estrogen exposure about?

Female sex is a protective factor for the progression of fibrosis in patients with chronic hepatitis C virus (HCV) infection. Experimental data suggest that estrogens may have an antifibrotic effect. The objective of this study was to evaluate the influence of past pregnancies, oral contraceptives, menopause, and hormone replacement therapy (HRT) on liver fibrosis progression in HCV-infected women. Four hundred seventy-two HCV-infected women received a survey regarding prior pregnancies, menopause, and the use of oral contraceptives and HRT. The impact of these variables on liver fibrosis and its progression were evaluated using multivariate analyses considering all putative confounding factors. Two hundred one women completed the survey (43% response rate), 157 of whom had an estimated date of HCV infection (96 postmenopausal women, 96 women with previous pregnancies, and 105 women with past use of oral contraceptives). Through multivariate analyses, the estimated rate of fibrosis progression was higher in postmenopausal (P < .05) and nulliparous (P ‫؍‬ .02) women and was associated with greater histological activity (P < .001). Prior use of oral contraceptives had no significant

Who reads Progression of liver fibrosis in women infected with hepatitis C: Long-term benefit of estrogen exposure?

Author

Vincent Di Martino; Pascal Lebray; Robert P. Myers; Emmanuelle Pannier; Valérie Paradis; Frédéric Charlotte; Joseph Moussalli; Dominique Thabut; Catherine Buffet; Thierry Poynard

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2004

Language

EN

Field

Medicine (Health Sciences)