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GLI1 Immunohistochemistry Distinguishes Mesenchymal Neoplasms With GLI1 Alterations From Morphologic Mimics by Paige H. Parrack; Adrian Mariño-Enríquez; Christopher D.M. Fletcher; Jason L. Hornick; David J. Papke is a Medicine article available to read on EtoBox.
What is GLI1 Immunohistochemistry Distinguishes Mesenchymal Neoplasms With GLI1 Alterations From Morphologic Mimics about?
Glioma-associated oncogene 1 (__GLI1__) alterations have been described in pericytoma with t(7;12), gastroblastoma, plexiform fibromyxoma, and an emerging class of __GLI1__-rearranged or amplified mesenchymal neoplasms including “nested glomoid neoplasm”. The immunophenotype of these tumor types is nonspecific, making some cases difficult to diagnose without sequencing. The utility of GLI1 immunohistochemistry (IHC) in distinguishing nested glomoid neoplasms and pericytomas with t(7;12) from morphologic mimics is unknown. To investigate the diagnostic value of GLI1 IHC, we determined its sensitivity and specificity in a “test cohort” of 23 mesenchymal neoplasms characterized by __GLI1__ alterations, including 12 nested glomoid neoplasms (7 __GLI1__-rearranged, 4 __GLI1__ amplified, and 1 unknown __GLI1__ status), 9 pericytomas with t(7;12), 1 gastroblastoma, and 1 malignant epithelioid neoplasm with __PTCH1__::__GLI1__ fusion. GLI1 IHC was 91.3% sensitive in this cohort; all tumors except 2 pericytomas with t(7;12) expressed GLI1. GLI1 was also expressed in 1 of 8 (12%) plexiform fibromyxomas. Nineteen of 22 GLI1-positive tumors showed nuclear and cytoplasmic staining, while 3 show
Who reads GLI1 Immunohistochemistry Distinguishes Mesenchymal Neoplasms With GLI1 Alterations From Morphologic Mimics?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Paige H. Parrack; Adrian Mariño-Enríquez; Christopher D.M. Fletcher; Jason L. Hornick; David J. Papke
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)