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Can I read Hybrid–Hybrid Relaxation Matrix Structural Refinement of Duplex DNA from Simulated 3D NOESY–NOESY Data on EtoBox?
Hybrid–Hybrid Relaxation Matrix Structural Refinement of Duplex DNA from Simulated 3D NOESY–NOESY Data by Frank Q. Zhu; David G. Donne; Elliott K. Gozansky; Bruce A. Luxon; David G. Gorenstein is a Chemistry article available to read on EtoBox.
What is Hybrid–Hybrid Relaxation Matrix Structural Refinement of Duplex DNA from Simulated 3D NOESY–NOESY Data about?
A hybrid-hybrid relaxation rate matrix refinement of 3D NOESY-NOESY data was tested by simulated refinement calculations on a dodecamer duplex DNA structure. 'Experimental' 3D data sets were generated from the known target structure for the simulated refinement. Theoretical 3D N0F.-NOE spectra were then calculated from several model-built structures. By scaling, the simulated experimental 3D data were merged with the theoretical 3D data to create a hybrid 3D NOESY-NOESY data set. This was then deconvoluted into a partial 2D hybrid volume matrix. The deconvoluted 2D hybrid NOESY data were then merged with the simulated 2D NOESY data (and, if available, additional experimental 2D data) to create a hybrid-hybrid 2D NOE volume matrix. Experimental 2D NOE data are not required for such a calculation. The hybrid-hybrid 2D data set was then used in an established 2D relaxation matrix procedure (MORASS) to produce distance constraints for restrained molecular dynamics refinement. The theoretical 3D data set and the model were refined in each iteration until agreement was obtained between the experimental and theoretical 3D NOESY-NOESY data sets. Two simulated 3D NOESY-NOESY data sets of th
Who reads Hybrid–Hybrid Relaxation Matrix Structural Refinement of Duplex DNA from Simulated 3D NOESY–NOESY Data?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Frank Q. Zhu; David G. Donne; Elliott K. Gozansky; Bruce A. Luxon; David G. Gorenstein
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; John Wiley and Sons Ltd; Wiley (ISSN 0749-1581)
- Published
- 1996
- Language
- EN
- Field
- Chemistry (Physical Sciences)