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Identification of Isomeric N ‐Glycans by Conformer Distribution Fingerprinting using Ion Mobility Mass Spectrometry by Javier Sastre Toraño; Oier Aizpurua‐Olaizola; Na Wei; Tiehai Li; Luca Unione; Gonzalo Jiménez‐Osés; Francisco Corzana; Victor J. Somovilla; Juan M. Falcon‐Perez; Geert‐Jan Boons is a Chemistry article available to read on EtoBox.
What is Identification of Isomeric N ‐Glycans by Conformer Distribution Fingerprinting using Ion Mobility Mass Spectrometry about?
## Abstract Glycans possess unparalleled structural complexity arising from chemically similar monosaccharide building blocks, configurations of anomeric linkages and different branching patterns, potentially giving rise to many isomers. This level of complexity is one of the main reasons that identification of exact glycan structures in biological samples still lags behind that of other biomolecules. Here, we introduce a methodology to identify isomeric __N__‐glycans by determining gas phase conformer distributions (CDs) by measuring arrival time distributions (ATDs) using drift‐tube ion mobility spectrometry‐mass spectrometry. Key to the approach is the use of a range of well‐defined synthetic glycans that made it possible to investigate conformer distributions in the gas phase of isomeric glycans in a systematic manner. In addition, we have computed CD fingerprints by molecular dynamics (MD) simulation, which compared well with experimentally determined CDs. It supports that ATDs resemble conformational populations in the gas phase and offer the prospect that such an approach can contribute to generating a library of CCS distributions (CCSDs) for structure identification.
Who reads Identification of Isomeric N ‐Glycans by Conformer Distribution Fingerprinting using Ion Mobility Mass Spectrometry?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Javier Sastre Toraño; Oier Aizpurua‐Olaizola; Na Wei; Tiehai Li; Luca Unione; Gonzalo Jiménez‐Osés; Francisco Corzana; Victor J. Somovilla; Juan M. Falcon‐Perez; Geert‐Jan Boons
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)