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Nifedipine and Nitrendipine Reactivity Toward Singlet Oxygen by Nancy A. Pizarro-Urzúa; Luis J. Núñez-Vergara is a Materials Science article available to read on EtoBox.

What is Nifedipine and Nitrendipine Reactivity Toward Singlet Oxygen about?

The ability to generate singlet molecular oxygen, O 2 ( 1 g ), and the scavenging activity of two well-known 1,4-dihydropyridines (1,4-DHPs) such as nifedipine (1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine-dicarboxylic acid dimethyl ester) and nitrendipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester) is assessed. Results show that nifedipine does not generate O 2 ( 1 g ) under our experimental conditions. In contrast, this 1,4-dihydropyridine behaves as a good scavenger of excited oxygen, mainly via physical deactivation with values of the total rate constant ranging from 20.8 × 10 5 M -1 s -1 in dioxane to 93.0 × 10 5 M -1 s -1 in propylencarbonate. The less favored reactive pathway generates a photooxidation product, which has been isolated and identified by GC-MS as the nitropyridine derivative. Voltammetric experiments also confirm the generation of this oxidation product. On the other hand, nitrendipine yields O 2 ( 1 g ), but it is a less efficient scavenger of this species. Rate constants range from 1.88 × 10 5 M -1 s -1 in ethyl acetate to 15.8 × 10 5 M -1 s -1 in N,N-dimethylacetamide, the reactive channel being

Who reads Nifedipine and Nitrendipine Reactivity Toward Singlet Oxygen?

Author

Nancy A. Pizarro-Urzúa; Luis J. Núñez-Vergara

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1010-6030)

Published

2005

Language

EN

Field

Materials Science (Physical Sciences)