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This study investigates the immune-modulatory effects of low-dose radiotherapy (LDRT) combined with PD-1 blockade in triple-negative breast cancer. Results indicate that LDRT, particularly at doses of 1.0-1.5 Gy, can delay tumor growth and reprogram the tumor microenvironment to enhance the efficacy of immune checkpoint inhibitors. The findings suggest that LDRT may serve as a promising strategy to improve treatment outcomes in patients resistant to conventional therapies.

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