Can I read Factor V Leiden in pregnancies complicated by placental abruption on EtoBox?

Factor V Leiden in pregnancies complicated by placental abruption by Martin Procházka; Catharina Happach; Karel Maršál; Björn Dahlbäck; Pelle G. Lindqvist is a Medicine article available to read on EtoBox.

What is Factor V Leiden in pregnancies complicated by placental abruption about?

**Objective** Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who have had of placental abruption during pregnancy. **Design** A retrospective case–control study. **Setting** University Hospital MAS, Malmö, Sweden. **Methods** A comparison of 102 women with placental abruption with 2371 prospectively collected controls. Carriership of FV Leiden was determined and the women were interviewed. **Main outcome measures** Proportion of FV Leiden carriership, first degree heritage of thrombosis and previous placental abruption in cases and controls. **Results** Carriage of FV Leiden was found in 15.7% of women who have had placental abruption as compared with 10.8% of controls (__P__= 0.12, odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.9–2.7). Around 20% of women with placental abruption reported first degree heritage for venous thrombosis, as compared with 6.7% of controls (__P__≤ 0.001). **Conclusions** FV Leiden carriership was not significantly

Who reads Factor V Leiden in pregnancies complicated by placental abruption?

Author

Martin Procházka; Catharina Happach; Karel Maršál; Björn Dahlbäck; Pelle G. Lindqvist

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1470-0328)

Published

2003

Language

EN

Field

Medicine (Health Sciences)