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Developmental Expression Profile of the Yy2 Gene in Mice by David Drews; Martin Klar; Christof Dame; Anja U Bräuer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Developmental Expression Profile of the Yy2 Gene in Mice about?

## Abstract ## Background The transcription factor Yin Yang 2 (YY2) shares a structural and functional highly homologue DNA-binding domain with the ubiquitously expressed YY1 protein, which has been implicated in regulating fundamental biological processes. However, the biological relevance of YY2 has not been identified yet. ## Results Towards the understanding of YY2 biology, we analyzed in detail the expression pattern of __yy__2 in various organs during embryonic and postnatal mouse development till adulthood. Thereby, a constant __yy2__ level was detected in heart and lung tissue, whereas in different brain regions __yy2__ expression was dynamically regulated. Interestingly, in any analyzed tissue neither the homologue __yy1__ nor the __mbtps2__ gene showed changes in mRNA expression levels like __yy2__, although the intronless __yy2__ gene is located within the __mbtps2__ locus. Furthermore, we detected __yy1__, __yy2__, and __mbtps2__ mRNA in primary mouse neurons, microglia cells, and astrocytes. In comparison to __yy2__ and __mbtps2__, __yy1__ revealed the highest expression level in all cell types. Again, only __yy2__ showed significantly altered gene expression levels am

Who reads Developmental Expression Profile of the Yy2 Gene in Mice?

Author

David Drews; Martin Klar; Christof Dame; Anja U Bräuer

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-213X)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)