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Time to maximum effect of lansoprazole on gastric pH in normal male volunteers by N. J. V. BELL; R. H. HUNT is a Medicine article available to read on EtoBox.

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__Background__: The time to maximum inhibition of gastric acidity resulting from repeated oral dosing with lansoprazole 30 mg daily for 7 days was studied in nine healthy male volunteers. __Methods__: Twenty‐four hour intragastric pH monitoring was performed before treatment and on days 1, 3, 5 and 7 of dosing with lansoprazole. Blood samples were taken for the estimation of plasma lansoprazole concentrations. __Results__: Lansoprazole 30 mg increased mean 24‐h intragastric pH to 3.57 on day 1 compared with baseline mean pH of 2.11 (__P__<0.05). The mean intragastric pH during the morning period (08.00–13.00 h) was significantly higher on days 3, 5 and 7 than on day 1, but no consistent differences between day 1, 3, 5 and 7 were noted for subsequent periods (13.00–18.00, 18.00–21.00 and 23.00–07.00 h). There were no differences in mean pH between days 3, 5 and 7. Intragastric pH was maintained above pH 3 for 54.7, 60.1, 61.9 and 67.4% of the time on days 1, 3, 5 and 7, respectively. Lansoprazole pharmacokinetic parameters did not change with daily dosing. The area under the lansoprazole plasma concentration–time curve correlated with the intragastric pH (__P__<0.005). __Conclusions

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Author

N. J. V. BELL; R. H. HUNT

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

1996

Language

EN

Field

Medicine (Health Sciences)