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Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis by Zhenyu Xiao; Ying Su; Shanmin Yang; Liangjie Yin; Wei Wang; Yanghua Yi; Bruce M. Fenton; Lurong Zhang; Paul Okunieff is a Medicine article available to read on EtoBox.

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Purpose: To investigate the effect of esculentoside A (EsA) on radiation-induced cutaneous and fibrovascular toxicity and its possible molecular mechanisms, both in vivo and in vitro. Methods and Materials: Mice received drug intervention 18 hours before 30 Gy to the right hind leg. Alterations in several cytokines expressed in skin tissue 2 days after irradiation were determined by ELISA. Early skin toxicity was evaluated 3 to 4 weeks after irradiation by skin scoring, and both tissue contraction and expression of TGF-␤1 were determined for soft-tissue fibrosis 3 months after irradiation. In vitro, the effect of EsA on radiation-induced nitric oxide (NO) and cytokine production in different cell types was measured by application of 2, 4, and 8 Gy. Results: In vivo, EsA reduced levels of IL-1␣, MCP-1, VEGF, and TGF-␤1 in cutaneous tissue and reduced soft-tissue toxicity. In vitro, EsA inhibited the IL-1␣ ordinarily produced after 4 Gy in A431 cells. In Raw264.7 cells, EsA reduced levels of IL-1␣, IL-1␤, and NO production costimulated by radiation and lipopolysaccharide (LPS). In L-929 cells, EsA inhibited VEGF, TNF, and MCP-1 production at 2, 4, and 8 Gy. Conclusions: Esculentoside

Who reads Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis?

Author

Zhenyu Xiao; Ying Su; Shanmin Yang; Liangjie Yin; Wei Wang; Yanghua Yi; Bruce M. Fenton; Lurong Zhang; Paul Okunieff

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2006

Language

EN

Field

Medicine (Health Sciences)